Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
The Sinclair Method (TSM) has emerged as a ground-breaking approach to reducing alcohol consumption through a medication-first strategy. By using Naltrexone to disrupt the brain’s reward cycle, it gradually helps people lose interest in alcohol.